Leukocyte and endothelial angiotensin II type 1 receptors and microvascular thrombotic and inflammatory responses to hypercholesterolemia.
نویسنده
چکیده
Angiotensin II (Ang II) exacerbates atherosclerosis in animal models with activated renin-angiotensin systems and hypercholesterolemia.1 Indirect evidence from trials in which angiotensin-converting enzyme inhibitors and Ang II type 1 receptor (AT1R) blockers were efficacious in decreasing cardiovascular events support the notion that Ang II plays a role in the pathogenesis of atherosclerosis clinically.2,3 AT1Rs mediate most of the physiological and pathophysiologic cardiovascular responses to Ang II.4 AT1Rs are involved in the pathophysiology of atherosclerosis.5
منابع مشابه
Endothelial Vasodilator Angiotensin Receptors are Changing in Mice with Ageing
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Angiotensin II type 1 (AT(1)) receptor signaling has been implicated in cerebral microvascular alterations associated with ischemia, diabetes mellitus, hypercholesterolemia, and atherosclerosis. Platelets, which express AT(1) receptors, also appear to contribute to the thrombogenic and inflammatory responses that are elicited by these pathological conditions. This study assesses the role of AT(...
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ورودعنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 26 2 شماره
صفحات -
تاریخ انتشار 2006